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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ABL1 Gene

protein-coding   GIFtS: 76

GCID: GC09P133589
c-abl oncogene 1, non-receptor tyrosine kinase
(Previous names: v-abl Abelson murine leukemia viral oncogene homolog 1, c-abl oncogene 1, receptor tyrosine kinase )
ABL1: Approved symbol from the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABL)
Biological research products
for ABL1    

Aliases &
Descriptions
for ABL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases & Descriptions
c-abl oncogene 1, non-receptor tyrosine kinase1 2     EC 2.7.10.23 8
ABL1 2 3     bcr/abl2
JTK71 2 3     bcr/c-abl oncogene protein2
p1501 2 3     proto-oncogene tyrosine-protein kinase ABL12
c-ABL1 2     tyrosine-protein kinase ABL12
c-abl oncogene 1, receptor tyrosine kinase1 2     v-abl2
v-abl Abelson murine leukemia viral oncogene homolog 11 2     Abelson murine leukemia viral oncogene homolog 13
Proto-oncogene c-Abl2 3     EC 2.7.108
Abelson tyrosine-protein kinase 12 3     

External Ids:    HGNC: 761   Entrez Gene: 252   Ensembl: ENSG000000970077   OMIM: 1899805   UniProtKB: P005193   

Export aliases for ABL1 gene to outside databases

Previous GC identifers: GC09P124604 GC09P125136 GC09P126943 GC09P128865 GC09P130619 GC09P132579 GC09P103075


Summaries
for ABL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ABL1:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes
of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively
regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation
results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic
myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by
CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or
7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
Function: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and
survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor
endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine
phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1
(involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN
(microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and
cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of
these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and
more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK,
inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other
substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the
CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads
to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of
lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial
dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved
in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6,
RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired.
Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates PSMA7 that leads to
an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple
pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been
identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of
pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin
repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host
actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally,
functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor,
ABI1

summary for ABL1:
The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2)
subtypes. c-Abl is localized at several subcellular sites including the nucleus, cytoplasm, mitochondria and
endoplasmic reticulum, where it interacts with a large variety of cellular proteins including signaling
adaptors, kinases, phosphatases, cell cycle regulators, transcription factors and cytoskeletal proteins. Due
to its diverse range of targets, c-Abl has been implicated in many cellular processes including regulation
of cell growth and survival, oxidative stress and DNA-damage responses, and actin dynamics and cell
migration. The Abl family have significant structural homology to the Src tyrosine kinase family, but have a
unique long carboxy-terminal extension that contains protein-protein interaction sites and acts as the
binding site for targets such as ATM, p53 and pRb. c-Abl is medically important as there is a causal link
between the Abl-Bcr fusion protein (caused by a t(9,22) translocation) and development of chronic myeloid
leukemia.

Gene Wiki entry for ABL1 (Abl gene)


Genomic Views
for ABL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 67), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABL1 gene promoter:
         NF-1   C/EBPbeta   STAT1   GATA-3   MyoD   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ABL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ABL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ABL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.12   HGNC cytogenetic band: 9q34.1

ABL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABL1 gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P133589:  view genomic region     (about GC identifiers)

Start:
 133,589,268 bp from pter
End:
 133,763,062 bp from pter
Size:
 173,795 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  

Proteins
for ABL1 gene

(According to 1UniProtKB, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images from SPIRE MOPED, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Sep 2012 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Epitomics, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519 (See protein sequence)
Recommended Name: Tyrosine-protein kinase ABL1  
Size: 1130 amino acids; 122873 Da
Cofactor: Magnesium or manganese
Subunit: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and
CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16, ITGB1 and HCK (By similarity). Interacts with
INPPL1/SHIP2. Interacts with the 14-3-3 proteins, YWHAB, YWHAE, YWHAG, YWHAH, SFN AND YWHAZ; the interaction with
14-3-3 proteins requires phosphorylation on Thr-735 and, sequesters ABL1 into the cytoplasm. Interacts with ABI1,
ABI2, BCR, CRK, FGR, FYN, HCK, LYN, PSMA7 RAD9A, RAD51, RAD52, TP73 and WASF3. A complex made of ABL1, CTTN and MYLK
regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated
endothelial cell (EC) barrier enhancement
Subcellular location: Cytoplasm, cytoskeleton. Nucleus. Mitochondrion (By similarity). Note=Shuttles between the
nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with
14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity)
Subcellular location: Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to
be nuclear
PDB 3D structures from and Proteopedia :
1AB2 (3D)    1ABL (3D)    1AWO (3D)    1BBZ (3D)    1JU5 (3D)    1OPL (3D)    1ZZP (3D)    2ABL (3D)    
2E2B (3D)    2F4J (3D)    2FO0 (3D)    2G1T (3D)    2G2F (3D)    2G2H (3D)    2G2I (3D)    2GQG (3D)    
2HIW (3D)    2HYY (3D)    2HZ0 (3D)    2HZ4 (3D)    2HZI (3D)    2O88 (3D)    2V7A (3D)    3CS9 (3D)    
3EG0 (3D)    3EG1 (3D)    3EG2 (3D)    3EG3 (3D)    3EGU (3D)    3K2M (3D)    3PYY (3D)    3QRI (3D)    
3QRJ (3D)    3QRK (3D)    3T04 (3D)    3UE4 (3D)    3UYO (3D)    
Secondary accessions: A3KFJ3 Q13869 Q13870 Q16133 Q17R61 Q45F09
Alternative splicing: 2 isoforms:  P00519-1   P00519-2   (Myristoylated on Gly-2)

Explore the universe of human proteins at neXtProt for ABL1: NX_P00519

Post-translational modifications:

  • Acetylated at Lys-711 by EP300 which promotes the cytoplasmic translocation1
  • Phosphorylation at Tyr-70 by members of the SRC family of kinases disrupts SH3 domain-based autoinhibitory interactions
    • and intermolecular associations, such as that with ABI1, and also enhances kinase activity. Phosphorylation at Tyr-226
    and Tyr-393 correlate with increased activity. DNA damage-induced activation of ABL1 requires the function of ATM and
    Ser-446 phosphorylation (By similarity). Phosphorylation at Ser-569 has been attributed to a CDC2-associated kinase
    and is coupled to cell division (By similarity). Phosphorylation at Ser-618 and Ser-619 by PAK2 increases binding to
    CRK and reduces binding to ABI1. Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic
    translocation. Phosphorylated by PRKDC (By similarity)1
  • Polyubiquitinated. Polyubiquitination of ABL1 leads to degradation1
  • Isoform IB is myristoylated on Gly-21
  • View modification sites using PhosphoSitePlus2

    • 4/19 DME Specific Peptides for ABL1 (P00519) (see all 19)
     RDLAARN  LFVALYD  LAYNKFS  ELVHHHS 

    Protein expression data from MOPED:
    Protein expression for ABL1
    About this image

    REFSEQ proteins (2 alternative transcripts): 
    NP_005148.2  NP_009297.2  

    ENSEMBL proteins: 
     ENSP00000361423   ENSP00000376971   ENSP00000323315   ENSP00000407756   ENSP00000400412  
    Reactome Protein details: P00519
    Human Recombinant Proteins: 
    EMD Millipore Purified and/or Recombinant ABL1 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ABL1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): ABL1
    GenScript Custom Purified and Recombinant Proteins Services for ABL1
    Novus Biologicals Proteins for ABL1
    Novus Biologicals Lysates for ABL1
    Sino Biological Recombinant Protein for ABL1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ABL1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS--
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737cytoplasm TAS--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    About this table

    ABL1 for ontologies           About GeneDecksing



    Antibodies for ABL1: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ABL1
    R&D Systems Antibodies for ABL1 (c-Abl) 
    Cell Signaling Technology (CST) Antibodies for ABL1  (Abl)
    OriGene Antibodies: ABL1
    GenScript Superior Antibodies for ABL1
    Novus Biologicals Antibodies for ABL1
    Epitomics antibodies for ABL1
    Uscn Antibodies for ABL1
    ThermoFisher Antibodies for ABL1 

    Assays for ABL1: 
    EMD Millipore Kits and Assays for the Analysis of ABL1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABL1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ABL1 (Abl)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ABL1

    Protein Domains /
    Families
    for ABL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ABL1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR015015 F-actin_binding
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P00519

    ProtoNet protein and cluster: P00519

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for ABL1 gene

    (According to 1UniProtKB, Genatlas, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Sep 12 2012,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, and DNA2.0, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Sep 2012 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
    Function: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and
    survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor
    endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine
    phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1
    (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN
    (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and
    cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of
    these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and
    more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK,
    inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other
    substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the
    CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads
    to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of
    lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial
    dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved
    in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6,
    RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired.
    Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates PSMA7 that leads to
    an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple
    pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been
    identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of
    pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin
    repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host
    actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally,
    functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor,
    ABI1
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker
    region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids.
    Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding
    to the SH2 and SH3 domains. Also stimulated by cell death inducers and DNA-damage. Phosphatidylinositol
    4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins,
    inhibits also the tyrosine kinase activity (By similarity). Inhibited by ABI1, whose activity is controlled by ABL1
    itself through tyrosine phosphorylation. Also inhibited by imatinib mesylate (Gleevec) which is used for the treatment
    of chronic myeloid leukemia (CML), and by VX-680, an inhibitor that acts also on imanitib-resistant mutants

         Genatlas biochemistry entry for ABL1:
    Abelson murine leukemia viral (v-abl) oncogene homolog 1,nucleocytoplasmic shuttling protein,with a loss from the
    nucleus upon adhesion to fibronectin matrix,,activated by certain DNA-damaging agents from ionizing radiation to
    alkylating agents,promoting cell cycle arrest by blocking the G/S transition-in a TP53 dependent way,regulated by
    ATM,requiring mitogen-activated protein kinase kinase 6 activation (MAP2K6) for inducing apoptosis,activating TP73 in
    a mismatch repair dependent apoptosis pathway and MAP2K6 (for CABL induced apoptosis)

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA:miRTarBase miRNAs that target ABL1: 
    hsa-mir-203 (MIRT003032)

    OriGene 3'-UTR Clone (see all 2): ABL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABL1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ABL1 (see all 21):
    hsa-miR-30c hsa-miR-125a-5p hsa-miR-30d hsa-miR-583 hsa-miR-3125 hsa-miR-3916 hsa-miR-30a hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmid: ABL1 3' UTR sequence
    Inhib.
    RNA:            		EMD Millipore RNAi Products for the Analysis of ABL1 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat  ABL1 (see all 5)
    OriGene shRNA RFP (see all 2): ABL1
    OriGene basic RS shRNA (see all 2): ABL1
    OriGene siRNA (see all 2): ABL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABL1

    Gene
    Editing:    		DNA2.0 Custom Protein Engineering Service for ABL1

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat  ABL1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat  ABL1 (see all 5)
    GenScript: all cDNA clones in your preferred vector (see all 2): ABL1 (NM_005157)
    Sino Biological Human cDNA Clone for ABL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABL1

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for ABL1
    Search LifeMap BioReagents cell lines for ABL1 

    In Situ
    Assays:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABL1

    Gene Ontology (GO): 5/18 molecular function terms (GO ID links to tree view) (see all 18):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000287magnesium ion binding IDA9144171
    GO:0003677DNA binding NAS8242749
    GO:0003785actin monomer binding TAS--
    GO:0004515nicotinate-nucleotide adenylyltransferase activity TAS--
    About this table

    ABL1 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for ABL1: 
     Decreased Salmonella enterica   Decreased circadian period len  Decreased focal adhesion (FA)   Decreased substrate adherent c 
     Increases Tamoxifen sensitivit 

    Animal Models:
         Mouse knock-outs for ABL1: Abl1tm1.1Gcos Abl1tm2.2Goff Abl1tm1Mlg Abl1m1
         15/18 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Abl1) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle  nervous system  normal 

    ABL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ABL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Sep 2012 via Entrez Gene).
    About This Section


    ABL1 for pathways           About GeneDecksing

    5 EMD Millipore Pathways for ABL1
        Transcription Transcription factor Tubby signaling pathways
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Slit-Robo signaling
    DNA damage DNA-damage-induced responses
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ABL1 (see all 10) 
        G-Protein Signaling through Tubby Protein
    Telomerase Components in Cell Signaling
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for ABL1
        Tyrosine Kinases / Adaptors

    5 GeneGo (Thomson Reuters) Pathways for ABL1
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Development Slit-Robo signaling
    Transcription Transcription factor Tubby signaling pathways
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    DNA damage DNA-damage-induced responses

    5/8 Reactome Pathways for ABL1 (see all 8)
        Hemostasis
    Developmental Biology
    Factors involved in megakaryocyte development and platelet production
    Role of Abl in Robo-Slit signaling
    Myogenesis

    1 PharmGKB Pathway for ABL1
        Imatinib Pathway, Pharmacokinetics/Pharmacodynamics

    5/9 Kegg Pathways  (Kegg details for ABL1) (see all 9):
        ErbB signaling pathway
    Cell cycle
    Axon guidance
    Neurotrophin signaling pathway
    Pathogenic Escherichia coli infection

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/358 Interacting proteins for ABL1 (P005191, 2, 3 ENSP000003614234) via UniProtKB, MINT, STRING, and/or I2D (see all 358)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC1P159412, 3, ENSP000003389834MINT-2880925 MINT-2881084 MINT-2881002 MINT-2881028 MINT-2880967 MINT-2881060 MINT-2880944 MINT-2881110 I2D: score=0.92 STRING: ENSP00000338983
    ABI1Q8IZP01, 2, 3, ENSP000003653124EBI-375543,EBI-375446 MINT-7385805 MINT-7385781 MINT-3390323 MINT-7907945 MINT-7385753 MINT-7385822 MINT-7385733 MINT-3390262 I2D: score=0.99 STRING: ENSP00000365312
    MSH5O431962MINT-7309811 MINT-7158451 MINT-7158702 MINT-7158714 MINT-7158402 MINT-7309724 MINT-7158255 MINT-7158347 MINT-7309863 MINT-7309845
    RIN1Q136711, 2, 3, ENSP000003104064EBI-375543,EBI-366017 MINT-59466 MINT-59455 MINT-59454 I2D: score=0.96 STRING: ENSP00000310406
    MAP4K1Q929181, 2, 3, ENSP000003800664EBI-375543,EBI-881 MINT-8110527 MINT-7213035 I2D: score=0.99 STRING: ENSP00000380066
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000115regulation of transcription involved in S phase of mitotic cell cycle TAS8242749
    GO:0006298mismatch repair TAS10391249
    GO:0006355regulation of transcription, DNA-dependent TAS8242749
    GO:0006464cellular protein modification process NAS8242749
    GO:0006468protein phosphorylation ----
    About this table

    ABL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ABL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, and/or Novoseek and Drugs according to DrugBank, Enzo Life Sciences PharmGKB, and/or TarThera)
    About This Section

    ABL1 for compounds           About GeneDecksing

    EMD Millipore small molecules for ABL1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ABL1

    Compounds for ABL1 available from Tocris Bioscience
    CompoundAction CAS #
    AP 24534Potent multi-kinase and pan-BCR-ABL inhibitor[943319-70-8]
    1-Naphthyl PP1Src family kinase inhibitor; also inhibits c-Abl[221243-82-9]
    About this table



    4 HMDB Compounds for ABL1
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    About this table



    10/11 DrugBank Compounds for ABL1 (see all 11)
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ImatinibImatinib Mesylate (see all 3)152459-95-5targetinhibitor16153117 15949566 16205964 15799618 15917650
    NilotinibAMN-107 (see all 2)641571-10-0targetinhibitor17715389 16721371 19920925 17929114 19822896
    Adenosine triphosphate5'-ATP (see all 8)56-65-5targetinhibitor17139284 11752352 17016423
    Dasatinib-- 302962-49-8targetmultitarget17701954 11752352 17016423
    1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA-- --target--10592235
    2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide-- --target--10592235
    2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE-- --target--10592235
    5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE-- --target--10592235
    6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE-- --target--10592235
    MYRISTIC ACID-- --target--10592235
    About this table


    10/44 Novoseek chemical compound relationships for ABL1 gene (see all 44)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 91.7 281 18835981 (5), 20020482 (5), 16205964 (3), 15510830 (3) (see all 99)
    tyrosine 87.4 511 9988744 (4), 11279131 (4), 11781820 (4), 11494128 (4) (see all 99)
    dasatinib 78.7 22 17155893 (2), 19062342 (2), 18326784 (2), 16721371 (1) (see all 10)
    adaphostin 66.7 5 17308109 (2), 17252018 (1)
    phosphotyrosine 65.4 15 1712111 (3), 12654250 (2), 8912843 (1), 10708759 (1) (see all 12)
    rottlerin 40.4 6 11707430 (1), 20043988 (1), 10713049 (1), 16631755 (1)
    phosphatidylinositol 40.2 17 9295282 (4), 16867995 (3), 1846663 (2), 14555967 (1) (see all 11)
    threonine 34.4 5 8691423 (1), 10637231 (1), 11840343 (1), 8816443 (1) (see all 5)
    cytarabine 30.6 11 8900110 (3), 8530447 (2), 12021410 (2), 9365241 (1)
    herbimycin a 28.6 2 1564963 (1), 8510919 (1)
    About this table

    2 PharmGKB related drug/compound annotations for ABL1 gene
    Drug/compound PharmGKB Annotation
    dasatinibDL  
    imatinibDL  
    About this table



    Transcripts
    for ABL1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 233 Homo sapiens; Sep 19 2012) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ABL1 gene (2 alternative transcripts): 
    NM_005157.4  NM_007313.2  

    Unigene Cluster for ABL1:

    C-abl oncogene 1, non-receptor tyrosine kinase
    Hs.431048  [show with all ESTs]
    Unigene Representative Sequence: NM_007313
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372348 ENST00000393293 ENST00000318560(uc004bzw.2) ENST00000438426(uc004bzx.1)
    ENST00000444970(uc004bzv.2)

    miRNA:  OriGene 3'-UTR Clone (see all 2): ABL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ABL1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ABL1 (see all 21):
    hsa-miR-30c hsa-miR-125a-5p hsa-miR-30d hsa-miR-583 hsa-miR-3125 hsa-miR-3916 hsa-miR-30a hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmid: ABL1 3' UTR sequence
    Inhib.
    RNA:             		EMD Millipore RNAi Products for the Analysis of ABL1 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat  ABL1 (see all 5)
    OriGene shRNA RFP (see all 2): ABL1
    OriGene basic RS shRNA (see all 2): ABL1
    OriGene siRNA (see all 2): ABL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ABL1
    Clones:  OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat  ABL1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat  ABL1 (see all 5)
    GenScript: all cDNA clones in your preferred vector (see all 2): ABL1 (NM_005157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ABL1
    Primers: OriGene genome-wide validated SYBR primer pairs in human, mouse, rat  ABL1 (see all 2)
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABL1

    Additional cDNA sequence: 

    AB209456.1 AB209642.1 AF533988.1 AK095344.1 AK294983.1 AM491359.1 AM491361.1 AY043457.1 
    AY789120.1 BC107069.1 BC107070.1 BC117451.1 DQ898314.1 EF158045.1 EF423615.1 EU447303.1 
    JF272500.1 M13096.1 M14752.1 M14753.1 M14754.1 M25946.1 M30833.1 X07537.1 
    X16416.1 X51945.1 

    16 DOTS entries:

    DT.75139099  DT.91761963  DT.121201653  DT.100033850  DT.40199015  DT.121201672  DT.121201747  DT.121201745 
    DT.97817099  DT.95228147  DT.87017796  DT.91724158  DT.95079826  DT.100734507  DT.121201744  DT.95129497 

    24/43 AceView cDNA sequences (see all 43):

    AK095344 BX099890 BM832613 CR614023 AL134822 CR598308 AL707819 BX097261 
    AA889856 BQ772414 X16416 AI025543 CA335983 H81821 AW206835 AA687347 
    NM_007313 AI084206 AI475681 BG955635 X51945 BX953746 M14753 NM_005157 

    GeneLoc Exon Structure


    Expression
    for ABL1 gene

    (RNA expression data according to H-InvDB, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or BioGPS, and/or EXPOLDB, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ABL1 expression in normal human tissues 
    About this imageCGAP TAG: AGGTACTGGT

    Microarray
    biogps.org
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See Protein Expression from SPIRE MOPED
    Genevestigator expression for ABL1 

    Expression variation in blood from EXPOLDB for ABL1

    UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including ABL1 (see all 12): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Apoptosis in human mouse rat
              Notch Signaling Targets in human mouse rat

    Primers: OriGene genome-wide validated SYBR primer pairs in human, mouse, rat  ABL1 (see all 2)
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ABL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ABL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ABL1
    In Situ
    Assays:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ABL1

    Orthologs
    for ABL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Sep 12 2012, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ABL1 gene from 6/22 species (see all 22)
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ABL11 v-abl Abelson murine leukemia viral oncogene homolog more 78.27(n)
    84.16(a)    		   417181  XM_001233811.1  XP_001233812.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ABL16
    		 c-abl oncogene 1, non-receptor tyrosine kinase
    		 77(a)
    		 1 ↔ 1
    		 1(11938-58507)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.190662 Transcribed sequence with moderate similarity to protein more 82.67(n)    142002072 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000007201 v-abl Abelson murine leukemia viral oncogene homolog more 70.3(n)
    75.63(a)    		   100000720  XM_001337793.3  XP_001337829.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Abl3 axon guidance protein tyrosine kinase 74(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea abl-13 Src homology domain 2, Src homology domain
    3, more    		 55(a)
    (best of 20)    		   X(10641430-10659377)   --
    About this table

    ENSEMBL Gene Tree for ABL1 (if available)

    Paralogs
    for ABL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ABL1 gene
    FRK2  LCK2  BLK2  ITK2  LYN2  YES12  TXK2  HCK2  
    BMX2  ABL22  SRMS2  TEC2  FGR2  PTK62  SRC2  FYN2  
    BTK2  
    SIMAP similar genes for ABL1 using alignment to 11 protein entries: ABL1_HUMAN(see all):
    BCR-ABL1 e19a2 BCR/ABL fusion BCR-ABL fusion BCR-ABL1 FER FLT3 MUSK TEK FES ABL2
    EPHA3 EPHA4 EPHA5 EPHA6 FLT1 RET ROR1 FYN BTK kinase deficient isoform 2 FRK
    FLT4 RET/PTC2 ROR2 CSK HCK BTK kinase deficient isoform 6 EPHB3 FGFR2 FGR TXK
    LCK BLK BTK kinase deficient isoform 4 EPHA2 EPHB2 EPHB2 variant protein GRAP GRAPL TYRO3 MET
    AXL BTK FGFR4 INSR JAK2 PTK6 NEK11 BTK kinase deficient isoform 3 CD74/ROS fusion EPHB1
    LYN ROS1 SLC34A2/ROS fusion SLC34A2/ROS1 fusion YES1 tec FGFR1 ALK DKFZp666O0110 EML4-ALK variant 6
    EML4-ALK variant 7 EML4/ALK fusion GRAP2 IGF1R KIF5B-ALK PPFIBP1-ALK PTK2 PTK2B SQSTM1-ALK TIE1
    lsk MST1R FGFR3 EGFR FPGT-TNNI3K c-fgr MERTK DDR1 SRC DKFZp434N1212
    ERBB4 GRB2 ITK MATK NTRK3 EPHA10 LTK NEK6 PDGFRB PKN2
    TEC urf-ret PTK7 BRSK2 DKFZp434L0319 DKFZp686M05208 ERBB2 ERBB3 TYK2 NEK9
    RYK RPS6KA1 RPS6KA2 SRMS MARK2 ZAK HUNK TNK2 BRAF JAK1
    STK25 NUAK1 MST4 STK24 TNK1 CAMK1 CDK1 MAPK14 MAP3K11

    ABL1 for paralogs           About GeneDecksing



    Genomic Variants
    for ABL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3406 NCBI SNPs in ABL1 are shown (see all 3406)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs74571,2
    		C,F,O,A,133762826(+) GTTAAC/TGTGAT 4 -- ref1 ut3129Minor allele frequency- T:0.25MN NS EA NA WA CSA 2847
    rs97621,2
    		F,A,H,133762553(+) TTCCCA/GCCCCT 4 -- ref1 ut31 ese314Minor allele frequency- G:0.38NS NA WA CSA EA 559
    rs107531,2
    		--133761923(+) GGCAGG/AGGACA 4 -- ut31 ref1 ese32Minor allele frequency- A:0.00MN NA 186
    rs119911,2
    		C,F,A,133762558(+) ACCCCT/CTCATA 4 -- ut31 ref1 ese328Minor allele frequency- C:0.30MN NS EA NA WA CSA 2649
    rs9137211,2
    		F133645683(+) GAAGCC/TGGGAG 1 -- int17Minor allele frequency- T:0.37NA WA EA 366
    rs9464861,2
    		F133646005(-) GCCAAG/ATAATT 1 -- int131Minor allele frequency- A:0.39NA NS EA WA CSA 2916
    rs10561691,2
    		F133760677(+) TCCACC/TGCCTT 4 T ref1 syn1 ese313Minor allele frequency- T:0.02NS NA WA 5502
    rs10561711,2
    		F133761001(+) GGTCCG/AGCGGC 4 /P ref1 syn1 ese338Minor allele frequency- A:0.40MN NA NS EA WA CSA EU 8346
    rs10561741,2
    		C,F,133761139(+) TACCCG/ATGACA 4 -- ut31 ref1 ese35Minor allele frequency- A:0.01NS 190
    rs10562091,2
    		C,F,O,133762590(+) GCACAG/AGCCCT 4 -- ut31 ref1 ese326Minor allele frequency- A:0.15MN NS EA NA WA CSA 2516
    About this table

    HapMap Linkage Disequilibrium images for ABL1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for ABL1
         7 CNVs: 3782 96316 83198 96318 7726 83199 96320
         6 Indels: 96319 96317 96321 29063 65533 83200

    5/14 SABiosciences Cancer Mutation PCR Assays for ABL1 (see all 14):
    Cosmic IdAA Change
    12611p.E355G
    12648p.F311L
    12608p.M244V
    12573p.E255K
    12610p.Y253F
    5/6 SABiosciences Cancer Mutation PCR Arrays containing ABL1 (see all 6):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Lymphoid Neoplasms
    Hematopoietic Neoplasms
    Cancer Comprehensive Panel 384HT
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ABL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ABL1

    Disorders / Diseases
    for ABL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, TarThera, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ABL1 for disorders           About GeneDecksing

    OMIM gene information: 189980   OMIM disorders: --
    UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
  • Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation
    • t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute
    lymphoblastic leukemia (ALL)

    20/93 diseases for ABL1 (see all 93): 
    leukemia    leukemia, philadelphia chromosome-positive, resistant to imatinib    myeloid leukemia    chronic myeloid leukemia
    gastrointestinal stromal tumor    ataxia telangiectasia    lymphoblastic leukemia    hypereosinophilic syndrome
    myeloproliferative disorder    burkitt's lymphoma    metastatic melanoma    myelodysplastic syndrome
    wilms tumor    acute leukemia    thyroid cancer    chondrosarcoma
    ovarian carcinoma    colon carcinoma    alzheimer's disease    prostate carcinoma

    About MalaCards

    3 diseases from the University of Copenhagen DISEASES database for ABL1: 
    Leukemia     Bone marrow cancer     Polycythemia vera

    10/55 Novoseek disease relationships for ABL1 gene (see all 55)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 91.9 112 18243808 (3), 2157692 (2), 16825513 (2), 7718887 (2) (see all 97)
    blast crisis 79.7 14 10822991 (2), 10190307 (2), 10498618 (2), 12759927 (2) (see all 7)
    leukemia 77.8 84 18257513 (3), 9341866 (3), 2163816 (2), 17959833 (2) (see all 67)
    lymphoblastic leukemia acute 70.4 12 8242587 (1), 8632666 (1), 11801308 (1), 15964830 (1) (see all 12)
    cml chronic phase 67.7 2 1736009 (1)
    myeloproliferative disorders 65.1 11 10490629 (2), 12767088 (1), 9490692 (1), 15616602 (1) (see all 8)
    minimal residual disease 62.2 1 16213363 (1)
    myeloproliferative neoplasm 59.2 4 18971950 (1), 19175693 (1)
    leukemogenesis 56.9 12 11387320 (2), 9790503 (1), 12887890 (1), 20082857 (1) (see all 7)
    gastrointestinal stromal tumor 54.4 4 15637141 (1), 15717993 (1), 15727903 (1), 18553235 (1)
    About this table


    Genetic Association Database (GAD): ABL1
    Human Genome Epidemiology (HuGE) Navigator: ABL1 (19 documents)
    Tumor Gene Database (TGDB): ABL1

    Export disorders for ABL1 gene to outside databases

    Publications
    for ABL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    10/1140 PubMed articles for ABL1 gene, integrated from 9 sources (see all 1140):
    (articles sorted by number of sources associating them with ABL1)
    1. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2, 9 Yoshida K.... Miki Y. (2005)
    2. c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization. (PubMed id 16648821)1, 2, 9 di Bari M.G....Barila D. (2006)
    3. Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. (PubMed id 10391250)1, 2, 9 Agami R....Shaul Y. (1999)
    4. Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. (PubMed id 7665185)1, 2, 9 Chissoe S.L.... Roe B.A. (1995)
    5. Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases. (PubMed id 19891780)1, 2, 9 Fernow I....Tikkanen R. (2009)
    6. Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK. (PubMed id 18161990)1, 2, 9 Jung J.H....Traugh J.A. (2008)
    7. Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104)1, 2, 9 Liu X....Cao C. (2006)
    8. Role of interfacial water molecules in proline-rich l igand recognition by the Src homology 3 domain of Abl. (PubMed id 19906645)1, 2, 9 Palencia A....Luque I. (2010)
    9. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. (PubMed id 10194451)1, 2, 9 Wisniewski D.... Clarkson B. (1999)
    10. Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution. (PubMed id 1281542)1, 2, 9 Overduin M.... Cowburn D. (1992)

    External Searches for ABL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ABL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25 HGNC: 76 AceView: ABL1 Ensembl:ENSG00000097007 euGenes: HUgn25
    ECgene: ABL1 Kegg: 25 H-InvDB: ABL1

    Other Databases showing ABL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ABL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ABL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ABL1 Genetics and Cytogenetics in Oncology and Haematology
    CGP resequencing studieshttp://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ABL1
    NIEHS-SNPshttp://egp.gs.washington.edu/data/abl1/
    Wikipedia http://en.wikipedia.org/wiki/Abl_gene

    Intellectual Property
    for ABL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ABL1 gene:
    Search GeneIP for patents involving ABL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
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    About This Section

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     ELISAs, CLIAs, Proteins, and Antibodies for ABL1
     Search LifeMap BioReagents cell lines for ABL1
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    GeneCards Homepage - Last full update: 11 Oct 2012 - Incremental updates: 18 Oct 2012 , 22 Oct 2012 , 25 Oct 2012 , 8 Nov 2012 , 15 Nov 2012 , 27 Nov 2012

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